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The production of HPMC begins with the natural polymer cellulose, which is sourced from wood pulp or cotton. The cellulose is first treated with a series of chemical reactions involving methylation and hydroxypropylation. This process modifies the molecular structure of cellulose, enhancing its solubility in water and improving its functional properties.
Molecular weight also plays a pivotal role in determining HPMC's solubility. Lower molecular weight HPMC is generally more soluble in organic solvents than its high molecular weight counterparts due to the reduced entanglement of polymer chains. This characteristic can be particularly important during the processing of drug formulations, where the solubility and viscosity of HPMC can significantly impact the release profile of the active pharmaceutical ingredient (API).
hpmc solubility in organic solvents
